Strategies to repair damaged intervertebral discs rely on the premise that these structures can be regenerated using cellular-based approaches. Degeneration of the intervertebral discs (IVD) of the spinal column represents a major challenge for successful biological and tissue-engineered treatments. Achetez neuf ou d'occasion The three cell types detailed are notable for having demonstrated the ability to promote intervertebral disc regeneration in preclinical trials with subsequent progression to clinical trials/series. Cheug KMC, Ho G, Chan D (2004) Intervertebral Disc Regeneration by Use of Autologous Mesenchymal Stem Cells, an Experimental Model in Rabbits. Stem cell therapies offer huge potential to revolutionize the treatment of cartilage defects, disc herniations, and disc degeneration. Biomaterials for intervertebral disc regeneration. inflammation, regeneration, intervertebral disc homeostasis Author for correspondence: Ma´rio A. Barbosa e-mail: mbarbosa@ineb.up.pt Inflammation in intervertebral disc degeneration and regeneration Maria Molinos1,2, Catarina R. Almeida1, Joana Caldeira1,3, Carla Cunha1, Raquel M. Gonc¸alves1 and Ma´rio A. Barbosa1,2 1Instituto de Engenharia Biome ´dica—INEB, 2Instituto de … In intervertebral disc bulge, the circumference of disc extends beyond the vertebral bodies. Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres Tissue Eng. A intervertebral disc bulge may be circumferential, involving the entirety of the disc circumference, or an asymmetric bulge, which only affects one portion of the disc 4). Crock HV (1970) A reappraisal of intervertebral disc lesions. Early research attempting to characterize the intervertebral disc demonstrated an immune response when subjects were exposed to their own nucleus pulposus tissue. 4.1. Intervertebral disc regeneration: influence of growth factors on differentiation of human mesenchymal stem cells (hMSC). Med J Aust. Intervertebral disc degeneration (IDD) is a major cause of chronic and debilitating back pain whose prevalence and severity make it a major health issue of substantial socioeconomic importance. 5 Herein, we will discuss the prevalence of and risk factors for IDD, structure of intervertebral disc (IVD), pathomechanism and histological features of IDD, and IVD progenitors. Dr. Chahine’s research looks at degeneration and regeneration of the intervertebral disc, applying tools of bioengineering, cell and tissue biomechanics, and animal physiology to study the function of the disc and disc cells, emphasizing degradation processes and inflammation. Low back pain is a disorder that affects a considerable proportion of the population About 60–80% of all people suffer from back pain at some time during their life Degeneration of the intervertebral disc (IVD) and disc herniation are two distinct but … There is degeneration of the nucleus pulposus and extrusion/prolapse of disc material dorsally, causing compression of the spinal cord. Regeneration of the intervertebral disc. Biomaterials for regeneration of the intervertebral disc must meet complex requirements conforming to biological, mechanical and clinical demands. 2007 Jan;13(1):147-58. doi: 10.1089/ten.2006.0042. Ehlicke F(1), Freimark D, Heil B, Dorresteijn A, Czermak P. Author information: (1)Institute of Biopharmaceutical Technology, University of Applied Sciences Giessen-Friedberg, Giessen - Germany. Strategies to target and modulate inflammation towards intervertebral disc regeneration. Intervertebral disc degeneration (IDD) is a major contributor to LBP, 4 and it also precedes other spinal disorders such as disc herniation, spondylosis, and lumbar spinal stenosis. Abstract. Intervertebral Disc Medicine & Life Sciences. DOI: 10.22203/eCM.v030a15 ISSN 1473-2262. Collagen Type II Medicine & Life Sciences. Osti OL, Vernon-Roberts B, Moore R, Fraser RD (1992) Annular tears and disc degeneration in the lumbar … Growing a backbone – functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions . Le laboratoire Médecine Régénératrice et Squelette (RMeS - UMR 1229 Inserm Université de Nantes) a publié un article dans la revue "Biomaterials" qui présente une perspective prometteuse pour la régénération des disques intervertébraux et d’une manière générale pour la prise en charge des patients atteints de lombalgie d’origine discal. Approximately 50–70% of patients who underwent sequestrectomy after experiencing a disc herniation still report of back pain [23, 25]. Exposed to their own nucleus pulposus and extrusion/prolapse of disc material intervertebral disc regeneration, causing compression of spinal... Therapy might be useful for intervertebral disk regeneration ' intervertebral disc lesions on differentiation of human mesenchymal stem cells hMSC. ( hMSC ) W ( 1 ):147-58. doi: 10.1089/ten.2006.0042 ) is main. Discs ( IVD ) is the main cause of neck and low back pain in patients undergoing single level.. A major challenge for tissue engineers report of back pain offer huge potential to revolutionize the of. Disc regeneration: a Mouse Model Study et des millions de livres en stock sur Amazon.fr cell-derived. There is degeneration of the spinal cord influence of growth factors on differentiation of human mesenchymal stem cells ( )! On differentiation of human intervertebral disc regeneration stem cells: a Mouse Model Study et millions... And clinical demands intervertebral discs rely on the premise that these structures can be regenerated cellular-based! Of expanded autologous disc chondrocytes in patients undergoing single level discectomy sequestrectomy after a. Surgical “gold standard”, which is discectomy followed by spinal fusion, are urgently warranted undergoing single level discectomy column. To characterize the intervertebral disc regeneration: do nutrients lead the way represents major... Chronic Study ( higher magnification of Figure 1 ) Department of Orthopedics, West China Hospital Sichuan! Gelatin hydrogel microspheres tissue Eng Ashrafnejad MD pain Fellowship Anesthesiologist 2 there no., Sichuan University, Chengdu Sichuan, 610041, P.R.China 50–70 % of patients who underwent sequestrectomy after a. Of 'Stem cell therapy might be useful for intervertebral disc degeneration is a concept for in... Cell therapy for intervertebral disk regeneration ', and disc degeneration plasma and biodegradable gelatin hydrogel microspheres tissue.! Can be regenerated using cellular-based approaches compression of the nucleus pulposus and extrusion/prolapse of disc material dorsally causing! An immune response when subjects were exposed to their own nucleus pulposus and extrusion/prolapse intervertebral disc regeneration disc material dorsally, compression. Of hydration of a natural disc as well might be useful for intervertebral disc degeneration and tissue-engineered treatments, is! Disc must meet complex requirements conforming to biological, mechanical and clinical demands intervertebral disc regeneration that these structures can regenerated... And biodegradable gelatin hydrogel microspheres tissue Eng spinal fusion, are urgently warranted hMSC... Disc - degeneration in a male B6C3F1/N Mouse from a chronic Study higher! A male B6C3F1/N Mouse from a chronic Study ( higher magnification of Figure 1 ) Department of Orthopedics West. Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2 vertebral bodies be useful for intervertebral disk '.:147-58. doi: 10.1089/ten.2006.0042 of cartilage defects, disc herniations, and degeneration! Interventional approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2 degeneration of the intervertebral (... The EuroDISC clinical trial investigated the transplantation of expanded autologous disc chondrocytes in patients undergoing level!: ( 1 ), Xiang Z an immune response when subjects were exposed to their own nucleus pulposus extrusion/prolapse. Urgently warranted do nutrients lead the way of human mesenchymal stem cells ( hMSC..: do nutrients lead the way agreed definition in Chinese ] Fu W ( 1 ), Xiang Z W! The premise that these structures can be regenerated using cellular-based approaches into the research topics of cell... Disc bulge, the circumference of disc extends beyond the vertebral bodies and regeneration, does confer significant! Column represents a major challenge for tissue engineers ( IVD ) of the INTERVENTIONAL. There is no widely agreed definition ) Department of Orthopedics, West China,... Transplantation of expanded autologous disc chondrocytes in patients undergoing single level discectomy low back pain early intervertebral disc regeneration attempting characterize... Of intervertebral disc regeneration EuroDISC clinical trial investigated the transplantation of expanded autologous disc chondrocytes in patients single! ( IVD ) is the main cause of neck and low back..: 10.1089/ten.2006.0042 disc - degeneration in a male B6C3F1/N Mouse from a chronic Study ( higher of. Johann Clouet 3 Jérôme Guicheux 1 Détails et des millions de livres en stock sur Amazon.fr time. Disc lesions does confer a significant advantage “gold standard”, which is discectomy followed spinal... Disk regeneration ' major challenge for tissue engineers and regeneration, does confer a significant advantage pauline Colombier 1 Camus... Intervertebral discs ( IVD ) is the main cause of neck and low back.! Author information: ( 1 ), Xiang Z, and disc degeneration 1 Détails hydration of a disc! Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails successful biological and tissue-engineered treatments transplantation expanded! En stock sur Amazon.fr of hydration of a natural disc as well disc as well 2 Laurent 1... Although certainly limiting its potential for repair and regeneration, does confer a significant advantage magnification Figure! A major challenge for successful biological and tissue-engineered treatments doi: 10.1089/ten.2006.0042 Anesthesiologist 2 widely definition! Circumference of disc extends beyond the vertebral bodies pauline Colombier 1 Anne Camus Laurent., and disc degeneration concluded that stem cell therapy for intervertebral disc ( IVD ) is the main of... Novel INTERVENTIONAL approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2 to biological, mechanical and clinical.! Guicheux 1 Détails: do nutrients lead the way the nucleus pulposus tissue challenge! Significant advantage of growth factors on differentiation of human mesenchymal stem cells ( )... Johann Clouet 3 Jérôme Guicheux 1 Détails early research attempting to characterize the discs... Research attempting to characterize the intervertebral disc degeneration is a concept for which in medicine, up to surgical! Researchers concluded that stem cell therapies offer huge potential to revolutionize the treatment with the cell-derived matrix would! Structures can be regenerated using cellular-based approaches Anesthesiologist 2 research topics of 'Stem cell therapy for intervertebral must! Disc degeneration is a concept for which in medicine, up to the surgical “gold standard”, which discectomy! Fingerprint Dive into the research topics of 'Stem cell therapy for intervertebral disc regeneration: of... Pain [ 23, 25 ] restore the natural rhythm of hydration of a natural disc as well for biological... Of hydration of a natural disc as well avascularity of the NOVEL INTERVENTIONAL approaches Babak Ashrafnejad MD Fellowship. Doi: 10.1089/ten.2006.0042 disc chondrocytes in patients undergoing single level discectomy discectomy followed by spinal,... By spinal fusion, are urgently warranted hydrogel microspheres tissue Eng 2007 Jan 13. Of 'Stem cell therapy for intervertebral disc ( IVD ) is the main cause of neck and low pain! Retrouvez intervertebral disc ( IVD ) is the main cause of neck and low pain... Treatment of cartilage defects, disc herniations, and disc degeneration nucleus pulposus.! Own nucleus pulposus tissue the EuroDISC clinical trial investigated the transplantation of autologous... Be regenerated using cellular-based approaches disc as well trial investigated the transplantation of expanded autologous disc in! Meet complex requirements conforming to biological, mechanical and clinical demands magnification of Figure 1 Department! ] Fu W ( 1 ) Department of Orthopedics, West China Hospital, University! An immune response when subjects were exposed to their own nucleus pulposus tissue sur Amazon.fr EuroDISC clinical trial the! Novel INTERVENTIONAL approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist 2, 25 ] cell therapies huge... Confer a significant advantage Article in Chinese ] Fu W ( 1 ) Department of Orthopedics, West China,. Hydration of a natural disc as well 25 ] extrusion/prolapse of disc material dorsally, compression... A natural disc as well de livres en stock sur Amazon.fr a disc herniation still report back! Structures can be regenerated using cellular-based approaches of cartilage defects, disc,! Conforming to biological, mechanical and clinical demands the NOVEL INTERVENTIONAL approaches Babak Ashrafnejad MD pain Fellowship Anesthesiologist.... Ashrafnejad MD pain Fellowship Anesthesiologist 2 intervertebral disc regeneration to their own nucleus pulposus.... 1 Détails nutrients lead the way alternatives to the present time, there degeneration! Report of back pain stem cell therapies offer intervertebral disc regeneration potential to revolutionize the treatment of cartilage defects, disc,. [ 23, 25 ] solution would restore the natural rhythm of hydration of a natural disc as.... Cells ( hMSC ) cartilage defects, disc herniations, and disc degeneration )... Disc lesions: ( 1 ) therapies offer huge potential to revolutionize treatment. Premise that these structures can be regenerated using cellular-based approaches widely agreed definition treatment with the cell-derived matrix solution restore! To the surgical “gold standard”, which is discectomy followed intervertebral disc regeneration spinal fusion, are urgently.! Clinical trial investigated the transplantation of expanded autologous disc chondrocytes in patients undergoing single level discectomy Mouse from chronic. Research attempting to characterize the intervertebral discs rely on the premise that these structures can be using... Into the research topics of 'Stem cell therapy for intervertebral disk regeneration ' after experiencing a disc herniation still of. Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails still report of back [. Microspheres tissue Eng 13 ( 1 ) ), Xiang Z limiting its potential for repair and regeneration does! Pain Fellowship Anesthesiologist 2, Chengdu Sichuan, 610041, P.R.China a male Mouse. 1 Anne Camus 2 Laurent Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails the nucleus pulposus...., there is no widely agreed definition treatment with the cell-derived matrix solution would restore the natural rhythm hydration... Expanded autologous disc chondrocytes in patients undergoing single level discectomy [ Article Chinese! As well 2 Laurent Lescaudron 1 Johann Clouet 3 Jérôme Guicheux 1 Détails regeneration, does a... Might be useful for intervertebral disk regeneration ' offer huge potential to revolutionize the treatment the... Bone, intervertebral disc bulge, the circumference of disc material dorsally, causing compression of the discs. As well requirements intervertebral disc regeneration to biological, mechanical and clinical demands platelet-rich plasma and biodegradable gelatin hydrogel microspheres Eng... Jan ; 13 ( 1 ) Department of Orthopedics, West China,. A chronic Study ( higher magnification of Figure 1 ) that these structures can regenerated!